Association between human gut microbiota and obesity according to Body Mass Index
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Published:
Aug 1, 2024
Keywords:
Microbiota, obesity, BMI.
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Abstract
Investigation about the gut microbiota as a tool to address obesity is a promising field. The influence of the microbiota on the endocrine system and host metabolism is crucial to understanding how it can affect body weight. For this review, relevant keywords such as "gut microbiota and obesity", "gut microbiota and BMI" and "gut microbiota composition" were used in the article search. 50 articles in English and Spanish were identified, of which 15 were selected that met the established inclusion criteria. Comparative studies that analyse the gut microbiota in groups of individuals from different regions of the world, according to their BMI classification, are especially valuable. 16S rRNA sequencing technology, based on the analysis of faecal samples, has consistently demonstrated a significant association between gut microbiota composition and BMI. Although specific bacteria that directly contribute to obesity have not yet been identified, certain predominant types have been observed in populations with this condition. Importantly, the types of bacteria associated with obesity can vary between studies, although predominant patterns can be identified in each BMI classification, particularly among lean and obese individuals. In the Peruvian context, the lack of studies on the association between the composition of the gut microbiome and obesity represents a significant opportunity. Future research in Peru could provide fundamental data to develop effective strategies for the prevention and treatment of obesity in the local population.
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Valdivia, A. V., Sanchez, S. Z., & Flores-León, D. (2024). Association between human gut microbiota and obesity according to Body Mass Index. Revista De Investigaciones De La Universidad Le Cordon Bleu, 11(2), 87-96. https://doi.org/10.36955/RIULCB.2024v11n2.008
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References
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Borgo, F., Garbossa, S., Riva, A., Severgnini, M., Luigiano, C., Benetti, A., Pontriroli, A., Morace, G., y Borghi, E. (2018). Body mass index and sex affect diverse microbial niches within the gut. Frontiers in Microbiology. 9. https://doi.org/10.3389/fmicb.2018.00213
Chávez-Carbajal, A., Nirmalkar, K., Pérez-Lizaur, A., Hernández-Quiroz, F., Ramírez-del-Alto, S., García-Mena, J., y Hernández-Guerrero, C. (2019). Gut Microbiota and Predicted Metabolic Pathways in a Sample of Mexican Women Affected by Obesity and Obesity Plus Metabolic Syndrome. International Journal of Molecular Sciences. 20(2):438. https://doi.org/10.3390/ijms20020438
Chen, J., Ryu, E., Hathcock, M., Ballman, K., Chia, N., Olson, J., y Nelson, H. (2016). Impact of demographics on human gut microbial diversity in a US Midwest population. PeerJ 4: e1514 https://doi.org/10.7717/peerj.1514
Ching-Hung, T., y Chun-Ying, W. (2019). The gut microbiome in obesity. Journal of the Formosan Medical Association. 118 (1) S3-S9
Davis, J., Collier, F., Mohebbi, M., Stuart, A., Loughman, A., Pasco, J., y Jacka, F. (2020). Obesity, Akkermansia muciniphila, and Proton Pump inhibitors: Is there a link? Obesity Research and Clinical Practice. 14(6):524–30. https://doi.org/10.1016/j.orcp.2020.10.006
Duan, M., Wang, Y., Zhang, Q., Zou, R., Guo, M., y Zheng, H. (2021). Characteristics of gut microbiota in people with obesity. PLOS ONE. 16(8). https://doi.org/10.1371/journal.pone.0255446
Ettehad, F., Moshiri, A., Sadat, M., Riazi, S., Taati, M., Sadati, S., Ghaheri, A., Masoomi, M., Vaziri, F., Fatet, A., Rohani, P., Tarashi, S., Masotti, A., Badi, S., y Siadat, S. (2020). The first report of differences in gut microbiota composition between obese and normal weight Iranian subjects. Iranian Biomedical Journal. 24(3):148–54. https://doi.org/10.29252/ibj.24.3.148
Gao X, Zhang M, Xue J, Huang J, Zhuang R, Zhou X, Zhang, H., Fu, Q., y Hao, Y. (2018). Body mass index differences in the gut microbiota are gender specific. Frontiers in Microbiology. 9. https://doi.org/10.3389/fmicb.2018.01250 https://www.sciencedirect.com/science/article/pii/S0929664618304376?via%3Dihub#bib9
Jinatham, V., Kullawong, N., Kespechara, K., Gentekaki, E., y Popluechai, S. (2018). Comparison of gut microbiota between lean and obese adult Thai individuals. Microbiology and Biotechnology Letters. 46(3):277–87. https://doi.org/10.4014/mbl.1711.11003
John, G., y Mullin, G. (2016). The Gut Microbiome and Obesity. Current Oncology Reports. 18(45). https://doi.org/10.1007/s11912-016-0528-7
Junjie, Q., Ruiqiang, L., Jeroen, R., Manimozhiyan, A., Kristoffer, S., Chaysavanh, M., Trine N., Nicolas, P., Levenez, F., Takuji Y., Mende, D., Junhua, L., Junming, X., Shaochuan, L., Dongfang, L., Jianjun, C., Bo, W., Huiqing, L., Huisong, Z … Wang, J. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464(7285): 59–65. https://doi.org/10.1038/nature08821
Kaplan, R., Wang, Z., Usyk, M., Sotres-Alvarez, D., Daviglus, M., Schneiderman, N., Gregory, A., Talavera, M., Gellman, B., Jee-Young M., Vázquez-Baeza, Y., McDonald, D., Williams-Nguyen, J., Wu, M., North, K., Shaffer, J., Christopher, C., Qibin, S., Isasi, C. … Burk, R. (2019). Gut microbiome composition in the Hispanic Community Health Study/study of Latinos is shaped by geographic relocation, environmental factors, and obesity. Genome Biology. 20(1). https://doi.org/10.1186/s13059-019-1831-z
Koliada, A., Syzenko, G., Moseiko, V., Budovska, L., Puchkov, K., Perederiy, V., Gavalko, Y., Dorofeyev, A., Romanenko, M., Tkach, S., Sineok, L., Lushchak, O., y Vaiserman, A. (2017). Association between body mass index and Firmicutes/Bacteroidetes Ratio in an adult Ukrainian population. BMC Microbiology. 17(1). https://doi.org/10.1186/s12866-017-1027-1
Lv, Y., Qin, X., Jia, H., Chen, S., Sun, W., y Wang, X. (2019). The association between gut microbiota composition and BMI in Chinese male college students, as analysed by next-generation sequencing. British Journal of Nutrition. 122(9), 986–995. doi: https://doi.org/10.1017/S0007114519001909
Oduaran, O., Tamburini, F., Sahibdeen, V., Brewster, R., Gómez-Olivé, F., Kahn, K. A., Norris, S. M., Tollman, R., Twine, A. N., Wade, R. G., Wagner, Z., Lombard, A., y Hazelhurst, S. (2020). Gut microbiome profiling of a rural and urban South African cohort reveals biomarkers of a population in lifestyle transition. BMC Microbiology. 20(1). https://doi.org/10.1186/s12866-020-02017-w
Org, E., Blum, Y., Kasela, S., Mehrabian, M., Kuusisto, J., Kangas, A.J., Pasi, S., Zeneng, W., Ala-Korpela, S., Markku, L., y Aldons, J. (2017). Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biology. 18(1). https://doi.org/10.1186/s13059-017-1194-2
Organisation for Economic Co-operation and Development (OECD). (2019). The Heavy Burden of Obesity: The Economics of Prevention, OECD Health Policy Studies, OECD Publishing, https://doi.org/10.1787/67450d67
Organización Mundial de la Salud (OMS). (2020). Obesidad. https://www.who.int/es/health-topics/obesity#tab=tab_1
Organización Mundial de La Salud. (2022). A different scale: Global action to address obesity. https://www.who.int/news-room/events/detail/2022/05/24/default-calendar/a-different-scale-global-action-to-address-obesity
Palmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., Uva, S., Vascellari, A., Loviselli, A., Manzin, A., y Velluzzi, F. (2021). Gut microbiota markers associated with obesity and overweight in Italian adults. Scientific Reports. 11(1). https://doi.org/10.1038/s41598-021-84928-w
Pinart, M., Dötsch, A., Schlicht, K., Laudes, M., Bouwman, J., Forslund, S.K., Pischon, T., y Nimptsch, K. (2022). Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis. Nutrients. 14 (12). https://doi.org/10.3390/nu14010012
Rubio, S., Pacheco-Orozco, R. A., Gómez, A. M., Perdomo, S., y García-Robles, R. (2020). Secuenciación de Nueva Generación (NGS) de adn: Presente y futuro en la práctica clínica. Universitas Médica.61(2). https:// doi.org/10.11144/Javeriana.umed61-2.sngs
Salah, M., Azab, M., Ramadan, A., y Hanora, A. (2019). New insights on obesity and diabetes from gut microbiome alterations in Egyptian adults. OMICS: A Journal of Integrative Biology. 23(10):477–85. https://doi.org/10.1089/omi.2019.0063
Yun, Y., Kim, H., Kim, S. E., Heo, S. G., Chang, Y., Ryu, S., Shin, H., y Hyung-Lae, K. (2017). Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort. BMC Microbiology. 17(1). https://doi.org/10.1186/s12866-017-1052-0